Analysis the differences of laboratory indexes among different types of neurosyphilis after penicillin treatment SHI Lu1，2） ，HUANG Yuming1，2） ，KOU Cheng1，2） ，XU Dongmei1，2） 1）Beijing Ditan Hospital，Capital Medical University，Beijing 100015，China； 2）National Center for Infectious Disease，Beijing 100015，China Corresponding author：XU Dongmei 【Abstract】 Objective To investigate the differences and influencing factors of laboratory indexes among asymptomatic neurosyphilis，tabes dorsalis and general paresis after penicillin treatment. Methods Totally of 50 HIV-negative neurosyphilis patients were enrolled，who were hospitalized in the Department of Neurology，Beijing Ditan Hospital，Capital Medical University including 16 patients of asymptomatic neurosyphilis，14 patients of tabes dorsalis and 20 patients of general paresis. The differences in peripheral blood and cerebrospinal fluid（CSF） indexes after treatment were compared among the three groups，and influencing factors of CSF protein and CSF TRUST titer were analyzed by Logistic regression. Results Post hoc multiple comparisons of peripheral blood lymphocytes（LY）and their subgroups showed that the count of LY in asymptomatic neurosyphilis was significantly higher than tabes dorsalis and general paresis，while the count of CD4+T lymphocytes in asymptomatic neurosyphilis was significantly higher than general paresis and the count of CD8+T lymphocytes in asymptomatic neurosyphilis was significantly higher than tabes dorsalis（P<0.05）. The CSF protein quantification of tabes dorsaliswas significantly higher than asymptomatic neurosyphilis and general paresis after treatment（P<0.05）. Logistic regression analysis showed that CSF protein of general paresis and asymptomatic neurosyphilis after treatment was more likely to be lower than tabes dorsalis （OR=0.169，95% CI：0.033-0.875，P=0.034；OR=0.092，95% CI：0.015-0.573，P=0.011）；CSF TRUST titer of tabes dorsalis and general paresis more likely to be higher than asymptomatic neurosyphilis（OR=15.298，95% CI：2.070-113.077，P=0.008；OR=14.736，95% CI：2.174-99.886，P=0.006）. Conclusion The differences in laboratory indexes among three types of neurosyphilis after penicillin treatment may be related to immune damage and pathological changes. Monitor the changes of laboratory indexes after treatment dynamically in order to predict the state and prognosis of illness，and formulate individualized and precise therapy. 【Key words】 Neurosyphilis；Clinical classification；Penicillin treatment；Laboratory indexes；Influencing factors
