Analysis of Laboratory Index before and after Neurosyphilis Treatment with cognitive dysfunction and abnormal mental behavior ZHANG Lei，GAO Junhua，LI Wurong，XU Dongmei Beijing Ditan Hospital Affiliated to Capital Medical University，Beijing 100015 China Corresponding author：XU Dongmei 【Abstract】 Objective neurosyphilis patients with cognitive dysfunction and abnormal mental behavior Analyze the changes of laboratory indicators before and after the treatment of ，and explore the method to evaluate the efficacy. Methods Between January 2015 and March 2020，we recorded blood TRUST titer，CSF TRUST titer，CSF routine WBC count，CSF protein quantification and Classification and evaluation of syphilis CSF test index baseline and follow-up results，and analyzed the changes before and after penicillin standard plum treatment. Results Of 70 patients，57 males and 13 females，with a mean age of（50.54±11.30）years. A total of 66 people completed the first follow-up，53 completed the second，34 completed the third，and 14 completed the fourth follow-up. Comparison of the composition ratios of various measures at different times after treatment，CSF TRUST，χ2=21.342，P<0.001 suggesting significant differences. For the CSF leukocyte count，the χ2=8.605P value was equal to 0.072，suggesting that the differential significance was not significant. CSF protein content，χ2=13.573，P<0.001，suggests a significant difference.Grading of syphilis CSF test index，χ2=37.247，P<0.001，suggesting a significant difference.Correlation between pairwise analysis of blood TRUST，CSF TRUST，CSF WBC count，CSF protein content and grading of syphilis CSF test index. At P=level 0.01，r=0.116 between CSF protein content and blood TRUST，the correlation was not significant. The remaining indicators showed significant correlation between pairwise，with r=0.820 between syphilis CSF test index grade and CSF TRUST，0.659 between CSF WBC count，and 0.593 between blood and CSF TRUST. Conclusion Regulating penicillin treatment is only effective in some neurosyphilis patients with cognitive dysfunction and abnormal mental behavior. CSF testing indicators differ in efficacy evaluation，and using CSF laboratory indicators for grading evaluation of such patients may be a simple method. 【Key words】 Neurosyphilis；Cognitive dysfunction；Mental behavior abnormalities；Cerebrospinal fluid；Laboratory tests
