与失眠神经生物机制相关的磁共振波谱研究进展
余天云 苏增锋
安徽医科大学附属巢湖医院，安徽 巢湖 238000
通信作者：苏增锋
【摘要】 睡眠可占用人一生近 1/3 的时间，是维持生命健康以及中枢神经系统正常功能不可或缺的生理过程。引起睡眠障碍的原因有很多，包括生理、心理、环境因素、精神疾病、躯体疾病以及药物因素等。随着失眠患者的不断增多，研究失眠的发病机制以及研发药物、开展更多治疗手段具有重要意义。但由于大脑生理结构的特殊性难以让研究者进行直观探索，因此，对失眠症发病机制的研究十分有限。磁共振波谱（magnetic resonance spectrum，MRS）作为目前唯一能够无创性地观察活体组织代谢及生化变化的技术，用于研究失眠患者大脑皮质脑代谢物及其变化规律，为探索失眠的发生机制与诊疗方法开辟了一个新的路径。
【关键词】 失眠；睡眠障碍；脑代谢物；发病机制；磁共振波谱
【中图分类号】 R256.23 【文献标识码】 A 【文章编号】 1673-5110 （2022） 05-0657-04
基金项目：安徽省转化医学研究院科研基金项目（编号：2021zhyx-C56）；安徽医科大学校科研基金 项目（编号：2020xkj219）
DOI：10.12083/SYSJ.220336
Advances in magnetic resonance spectroscopy analysis related to the neurobiological mechanism of insomnia
YU Tianyun，SU Zengfeng
Chaohu Hospital Affiliated to Anhui Medical University，Chaohu 238000，China
Corresponding author：SU Zengfeng
【Abstract】 Sleep can take up nearly one-third of a person’s life，which is an indispensable physiological process for maintaining life and health and the normal function of the central nervous system. There are many causes of sleep disorders，including physical，psychological，environmental factors，mental diseases，somatic diseases and drug factors. With the increasing number of patients with insomnia，it is of great significance to study the pathogenesis of insomnia，develop drugs and carry out more treatment methods. However，due to the particularity of the physiological structure of the brain，it is difficult for researchers to explore intuitively，the study of the pathogenesis of insomnia is very limited. Magnetic resonance spectrum（MRS），as the only technology that can non-invasively observe the metabolism and biochemical changes of living tissue，is used to measure and study the brain metabolites in the cerebral cortex of patients with insomnia and their changes，opening up a new path to explore the mechanism and diagnosis and treatment of insomnia.
【Key words】 Insomnia；Sleep disorders；Brain metabolites；Pathogenesis；Magnetic resonance spectrum
