关键词 / KeyWords：
阿尔茨海默病,脑白质高信号,脑白质病变,认知障碍,精神症状
脑白质高信号与阿尔茨海默病的相关性研究进展
梁春华 肖小华
深圳大学第一附属医院，广东 深圳 518035
通信作者：肖小华
【摘要】 阿尔茨海默病是一种老年人最常见的痴呆症，是一个日益严重的全球健康问题。脑白质高信号是脑白质病变的影像学表现，近些年神经影像学研究发现脑白质高信号是认知障碍发生发展的重要危险因素。现就脑白质高信号的病因、发病机制及其与阿尔茨海默病病理、认知功能等方面内容进行阐述。
【关键词】 阿尔茨海默病；脑白质高信号；脑白质病变；认知障碍；精神症状
【中图分类号】 R742.5 【文献标识码】 A 【文章编号】 1673-5110 （2022） 04-0513-05
DOI：10.12083/SYSJ.220224
Research progress of the correlation between high white matter signal and Alzheimers disease
LIANG Chunhua，XIAO Xiaohua
The First Affiliated Hospital of Shenzhen University，Shenzhen 518035，China
Corresponding author：XIAO Xiaohua
【Abstract】 Alzheimer，and it is a growing global health problem. White matter hyperintensity is an imaging manifestation of white matter lesions. In recent years，neuroimaging studies have found that white matter hyperintensity is an important risk factor for the development of cognitive impairment. This article first summarizes the etiology，pathogenesis and severity assessment of white matter hyperintensity，and then explains the relationship between white matter hyperintensity and Alzheimers disease pathology，cognitive function，and psychiatric symptoms.
【Key words】 Alzheimer；White matter hyperintensity；White matter lesions；Cognitive impairment；Mental symptoms
