纹状体及其环路参与孤独症重复刻板行为机制研究进展
樊亚蕾 李恩耀 赵鹏举 郝汇睿 徐成铭 张 哲 董献文△
郑州大学第五附属医院 河南省康复医学重点实验室，河南 郑州 450052
基金项目：河南省卫健委省部共建重点项目（编号：SBGJ202002123）；河南省高等学校重点科研项目（编号：21A320058）；河南省医学科技攻关计划联合共建项目（编号：LHGJ20200484）
作者简介：樊亚蕾，Email：fanfyl123456@163.com
△通信作者：董献文，Email：xianwen.2004@163.com
【摘要】 重复刻板行为是孤独症谱系障碍的核心症状之一，病因复杂，表现形式多样。其形成机制假说众多，近年来有研究显示纹状体功能异常可能参与了孤独症重复刻板行为演变过程。本文拟对纹状体及其环路参与孤独症重复刻板行为相关机制研究进展进行综述，期望推动孤独症重复刻板行为机制研究。
【关键词】 孤独症谱系障碍；重复刻板行为；纹状体；纹状小体；神经机制
【中图分类号】 R749.93 【文献标识码】 A 【文章编号】 1673-5110 （2021） 24-2184-10
DOI：10.12083/SYSJ.2021.24.021
Research progress on the mechanism of striatum and its circuitry involved in restricted repetitive behaviors in autism
FAN Yalei，LI Enyao，ZHAO Pengju，HAO Huirui，XU Chengming，ZHANG Zhe，DONG Xianwen
The Fifth Affiliated Hospital of Zhengzhou University/Key Laboratory of Rehabilitation Medicine of Henan Province， Zhengzhou 450052，China
【Abstract】 Restricted repetitive behavior is one of the core symptoms of autism spectrum disorder. The eti⁃ology are complex and its manifestations are diverse.There are many hypothesis about its formation mechanism. In recent years，studies have shown that the abnormal function of the striatum may be involved in the evolution of re⁃ stricted repetitive behaviors in autism.This article intends to review the research progress of the striatum and its cir⁃ cuitry involved in the restricted repetitive behaviors of autism. Expectation to promote research on the mechanism of restricted repetitive behaviors in autism.
【Key words】 Autism spectrum disorder；Restricted repetitive behaviors；Striatum；Striosomes；Neural mechanisms