外泌体在癫痫诊疗中的研究进展
栗 静 胡风云 刘 毅
山西医科大学第五临床医学院，山西 太原 030000
通信作者：胡风云
【摘要】 外泌体是不同类型细胞释放的一种细胞外囊泡，富含多种生物活性分子，如 RNA、蛋白质和脂质。大量研究表明，外泌体通过促进细胞间通信和调节细胞对外部环境的反应，在许多疾病生理和病理过程中发挥着关键作用。特别是在中枢神经系统中，外泌体可能在许多神经系统疾病中发挥作用，如神经元发育异常、神经退行性疾病、癫痫、精神障碍、卒中、脑损伤和脑肿瘤。由于外泌体再现了亲代细胞的特征，并有能力穿过血脑屏障，它们的内容物可以作为早期诊断和临床评估神经系统疾病治疗的潜在生物标志物。本文就血清外泌体在癫痫诊疗中的研究进展作一综述，为将来寻找癫痫理想诊断标志物及治疗干预靶点提供新的思路。
【关键词】 外泌体；癫痫；诊断；治疗；研究进展
【中图分类号】 R742.1 【文献标识码】 A 【文章编号】 1673-5110 （2022） 08-1012-05
基金项目：吴阶平医学基金会（编号：320.6750.16129）；山西省科学技术厅（编号：201603D321060）
DOI：10.12083/SYSJ.220561
Research progress of exosome in the diagnosis and treatment of epilepsy
LI Jing，HU Fengyun，LIU Yi
The Fifth Clinical Medical College of Shanxi Medical University，Taiyuan 030000，China
Corresponding author：HU Fengyun
【Abstract】 Exosomes are extracellular vesicles released by different types of cells，rich in a variety of biologically active molecules，such as RNA proteins and lipids. Numerous studies have shown that exosomes play a key role in the physiological and pathological processes of many diseases by promoting cell-cell communication and regulating cellular responses to the external environment Especially in the central nervous system，exosomes may play a role in a number of neurological disorders，such as neuronal dysplasia，neurodegenerative diseases，epilepsy，psychiatric disorders，stroke，brain damage and brain tumors Due to the outside of a parental cells secrete body characteristics，and has the ability to cross the blood-brain barrier，their contents can be used as early diagnosis and clinical evaluation potential biomarkers of nervous system diseases treatment In this paper，the s⁃rum secrete body outside the review summarized the research progress in diagnosis and treatment of epilepsy，epilepsy，ideal for future diagnostic markers and therapeutic targets for intervention to provide new ideas.
【Key words】 Exosome；Epilepsy；Diagnosis；Treatment；The research progress
