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肠道菌群与抑郁症的关系研究进展

作者 / Author:陈铭杨 王谨敏

肠道菌群与抑郁症的关系研究进展
陈铭杨1) 王谨敏2) 
1)福建中医药大学,福建 福州 350122  2)福建中医药大学附属第二人民医院,福建 福州 350003
通信作者:王谨敏
摘要】 抑郁症是一种高发病率、高复发率、高自杀率及高致残率的慢性发展性精神障碍。它给人们带来的不仅仅是巨大的精神压力,还有经济压力,给社会也带来巨大的经济压力。目前对于抑郁症关键发病机制的解释仍不明确,研究认为,胃肠道的微生物群与宿主之间存在着一种复杂的联系,即“脑-肠”轴,这一理论已经成为抑郁症治疗的一个全新发展方向,故本文综述近年来肠道菌群与抑郁症关系的研究进展,希望能为抑郁症的治疗提供一些新的借鉴及依据。
关键词】 抑郁症;“脑-肠”轴;肠道菌群;神经系统疾病;胃肠道疾病

中图分类号R749.4 文献标识码A文章编号 1673-5110 (2022) 08-1023-07
基金项目:福建中医药大学“中医脾胃优势特色学科”建设项目(编号X2019012);福建省卫生厅基金资助项目(编号zlcxn09
DOI:10.12083/SYSJ.220644
 
Research progress on the relationship between intestinal flora and depression
CHEN Mingyang1 ,WANG Jinmin2 
1)Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;
2)The Second People’s Hospital
Affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350003,China
Corresponding author:WANG Jinmin
Abstract】 Depression is a chronic developmental mental disorder with high incidence rate,high recurrence rate,high suicide rate and high disability rate. It brings people not only great spiritual,but also economic pressure,and brings great economic pressure to the society. At present
,the explanation of the key pathogenesis of depression is still not clear,but the current research believes that there is a complex relationship between the microbiota of the gastrointestinal tract and the host,that is,the“brain gut”axis. This theory has become a new development direction for the treatment of depression. Therefore,this paper reviews the research progress on the relationship between intestinal flora and depression in recent years,hoping to provide some new reference and basis for the treatment of clinical depression.
【Key words】 Depression;“brain gut”axis;Intestinal flora;Nervous system diseases;Gastrointestinal diseases

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