深髓静脉与脑小血管病研究进展
尹园园 罗伟刚 任慧玲
河北医科大学第三医院，河北 石家庄 050011
通信作者：任慧玲
【摘要】 脑小血管病（CVSD）是一类常见的疾病。虽然 CVSD 主要影响脑动脉小血管的病理，但脑实质的小静脉逐渐被关注，特别是引流深部白质的深髓静脉（DMVs）。随着 3.0T 磁共振，特别是磁敏感加权成像（SWI）的发展，使得 DMVs 的结构可以清晰显现。该文综述了 DMVs 在 CVSD 发展中的作用。DMVs可能参与了脑小血管病的病理过程，重视 DMVs 的影像学表现可以为疾病的发展和预后提供更多信息。DMVs 与 CVSD 神经影像学标志物之间的关系提示了小静脉在与年龄相关的神经退行性过程中的潜在作用，值得进一步研究。
【关键词】 深髓静脉；脑小血管病；磁敏感加权成像；年龄；神经退行性疾病
【中图分类号】 R743 【文献标识码】 A 【文章编号】 1673-5110 （2022） 07-0911-05
基金项目：河北省重点科技研究计划项目（编号：20170651）
DOI：10.12083/SYSJ.220483
Advances in the research of deep medullary veins and cerebral small vessel disease
YIN Yuanyuan，LUO Weigang，REN Huiling
The Third Hospital of Hebei Medical University，Shijiazhuang 050011，China
Corresponding author：REN Huiling
【Abstract】 Cerebral small vessel disease （CSVD） are prevalent. Although arteriolar disease has been implicated in their pathogenesis，venous pathology warrants consideration，especially the deep medullary veins （DMVs）that drain deep white matter. with increased use of 3-T imaging such as susceptibility weighted imaging （SWI）that can be used to visualize venous structures，understanding of the structure of venous anatomy has become feasible. In this review article，we will describe CVSD in which the DMVs play a major role in disease development. DMVs involved pathomechanism may participate in the CSVD development. Attach importance to DMVs radiological profile in CSVD will provide more neuroimaging information for diagnosis and prognosis. the significant association between DMVs and CVSD neruoimage markers suggested the potential role of venules in age-related neurodegenerative process，which deserves further investigation.
【Key words】 Deep medullary veins；Cerebral small vessel disease；Susceptibility weighted imaging；Age；Neurodegenerative diseases
