【摘要】 睡眠障碍是阿尔茨海默病（AD）的常见症状，通常被认为是神经退行性过程的晚期后果。最近研究表明，睡眠障碍通常发生在疾病的早期，甚至可能先于认知症状出现。此外，睡眠-觉醒周期似乎可以调节大脑中致病的β淀粉样蛋白（Aβ）水平，并通过多种机制影响小鼠模型中与 AD 相关的病理。最后，睡眠剥夺似乎加剧了小鼠的 Aβ病理，并且除了 Aβ的改变外，睡眠剥夺可通过多种机制介导 Aβ非依赖性神经元损伤。本综述研究了睡眠障碍可能影响 AD 发病机制的有关文献，并深入探讨其可能的机制。 【关键词】 阿尔茨海默病；睡眠障碍；睡眠-觉醒周期；睡眠剥夺；β淀粉样蛋白 【中图分类号】 R749.1+6 【文献标识码】 A 【文章编号】 1673-5110 （2022） 06-0781-04 基金项目：大连市卫计委科研课题项目（编号：2011049） DOI：10.12083/SYSJ.220421
Research progress on the relationship between sleep disorders and Alzheimer’s disease WANG Xiu1） ，TANG Wei1） ，TAN Liyang1） ，WANG Wei2） 1）Xinhua Hospital，Dalian University，Dalian 116621，China 2）Zhongshan Hospital，Dalian University，Dalian 116001，China Corresponding author：TAN Liyang，Email：tanliyang780610@163.com；Email：WANG Wei，Email：ww19791010@aliyun.com 【Abstract】 Sleep disturbances are a common symptom of Alzheimer ’s disease（AD）and are often considered a late consequence of neurodegenerative processes. Recent studies have shown that sleep disturbances usually occur early in the course of the disease and may even precede the appearance of cognitive symptoms. In addition，sleep-wake cycles appear to regulate levels of pathogenic β amyloid（Aβ）in the brain and influence AD-associated pathologies in mouse models through multiple mechanisms. Finally，sleep deprivation appears to exacerbate Aβ pathology in mice，and in addition to alterations in Aβ，sleep deprivation can mediate Aβ non-dependent neuronal damage through a variety of mechanisms. This review examines the literature that sleep disorders may affect the pathogenesis of AD and explores its possible mechanisms in depth. 【Key words】 Alzheimer’s Disease；Sleep Disorders；Sleep-wake cycle；Sleep deprivation；Amyloid β-protein
